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What Does Lithium Orotate Do to the Brain?

What Does Lithium Orotate Do to the Brain?

In the alternative and integrative medical community, lithium orotate has been used for prevention and treatment for a variety of mental health conditions. For over a century, doctors have seen merit in using lithium (not lithium orotate) for mental conditions. However, its use diminished due to side effects that concerned the FDA. In the last forty years, integrative medicine has become more relevant, and the use of minerals, amino acids, and vitamins have been part of the western medicine world.

The use of the mineral has expanded to beyond mental health. It can help uric acid levels be lowered in patients with gout and help with skin rashes and other biologic disorders. At a low dose, it can supplement patients with bipolar disorder treatment.

Alzheimer's, dementia, ALS, clinical depression, PTSD, OCD, and general anxiety can also be assisted by the mineral and other conditions as seen fit by your medical doctor. To understand its value in health care further, read about what it is and the laundry list of conditions it can help.

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What Is Lithium Orotate?

Lithium orotate is a mineral, not a drug.  It is different from the pharmaceutical version that a doctor would prescribe called lithium carbonate. The orotate version is a mineral and white powder sold OTC in capsule form. It contains lithium which protects brain cells, the blood-brain barrier and can regrow brain cells.

It has many other uses in the brain and body. It is an alkali metal and orotic acid. The orotic acid naturally produced by our bodies in the intestines and is sometimes called vitamin B 13.  B 13 is not an actual B vitamin; it is just referred to as one.

Psychiatry professionals use this as an alternative medicine treatment used instead of prescription lithium.  They have used it to prevent episodes of mania in people with bipolar disorder.  The mood stabilizing effects of lithium orotate can help with anger, depression, PTSD and other disorders with similar symptoms.

A variety of other kinds of medical conditions can benefit from lithium orotate. The dosing varies on the medical conditions a patient may suffer from. In high levels, the mineral can be toxic and affect heart and kidney patients.

Medical Conditions That Benefit From The Supplement:

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Benefits For Various Conditions 

It is best to consult with an integrative medicine doctor to see if lithium orotate is beneficial for you and what dose you should take. As with any supplement, make sure there are no interactions with current medications and OTD supplements you are taking.

In the 1970s and 80s studies showed a variety of benefits to taking lithium. Today, however, we lack in greater studies for the benefit of use. Lithium orotate can improve memory, reduce stress and help relieve pain.

Bipolar Disorder, Anxiety from PTSD

Patients with bipolar disorder can use lithium orotate with their lithium prescription to improve symptoms. The acid in lithium orotate can help increase absorption of prescription lithium carbonate. It can also help decrease the prescription version.


There isn't much scientific material showing the orotate used solely for bipolar as a replacement to regular lithium. It can also benefit those who have severe anxiety from PTSD and can help as a mood stabilizer for panic attacks.

Alcoholism, Addiction Disorders, OCD, Obsessive Disorders

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In the mid-80s an alcohol study was done and found that daily treatment assisted alcoholics in their journey to quit drinking. The benefit of helping other addictive behavioral conditions is there. Those who suffer from OCD and obsessive disorders can benefit from it. The mineral can help cope during the rehabilitation process besides using counseling therapy.

Suicide Prevention, Mood Stabilization

The mineral can help with people suffering from depression and clinical depression. The effectiveness in prevention of suicide also is a benefit for sufferers. They place many people on antidepressants however the prescriptions have severe side effects. They can cause a person to be more restless, irritable, violent, angry and impulsive.


This is where lithium orotate comes in. There are no severe side effects of lithium orotate known. This is only at toxic levels. This could be a better alternative for mood stabilization and suicide risk patients. It is a valued mood stabilizer for this kind of anxiety.

Neurological conditions, ADD, ADHD

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There is literature that supports the use of lithium orotate in a variety of neurological conditions. These conditions include Alzheimer's and dementia patients, ADD and ADHD, and violent and aggressive behaviors.


Studies have determined that giving lithium to dementia patients. It can help with behavioral and biologic issues. It can be a positive impact for Alzheimer's-dementia patients as well. It has proven to keep neurons alive in animals and humans.  It has shown this in several studies. Improved focus can help ADD patients. Those who have ADHD can also be stabilized.

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Side Effects And Drug Interactions

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In high levels, the supplement can be toxic.  Always discuss options with your medical doctor the benefits versus the risks before using it as a supplement. Long-term side effects of lithium orotate are unknown however there is a benefit to the short-term. The mineral shouldn't be used if you are breastfeeding or have a serious cardiovascular disease.

You shouldn't take it if you take diuretics or ACE inhibitors; have sodium depletion issues or renal failure. If you are already on an anti-depressant, talk to your doctor. Some combinations can be dangerous. Sometimes doctors use the orotate kind with other medications. This all depends on your mental conditions and diagnosis. These main risks are below.

Reported Side Effects With Toxicity:

Drug Interactions:

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Dosage For Conditions

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There are numerous benefits to taking lithium orotate in low dosages. Here are some other benefits. The typical dose is between five and 20 mg. They can also give it in liquid form, typically around 250mcg. At this dose, it's not toxic.

Most side effects are with lithium carbonate, the prescription version. You should always talk to your healthcare professional about using lithium orotate so they can monitor you. You should never buy street drugs for any chronic condition; it can have serious consequences.

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What Does It Do to the Brain?

Lithium orotate protects the brain by preventing the loss of brain cells and produce new brain cells. It has shown to reverse Parkinson's, Alzheimer's disease and dementia. Animal studies the lithium orotate showed improvement in traumatic brain injuries and strokes. It can also be beneficial as a protectant in central nervous system damage due to Lyme disease and can also protect from brain shrinkage.

  • Other Benefits:
  • Protects Brain Cells From Infections And Toxins
  • Can Help Boost Immune System
  • Can Help Increase Longevity
  • Grows New Brain Cells
  • improves mitochondrial function
  • assists with bone health
  • can decrease insulin resistance
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History of Lithium

Between 1850 and 1890 physicians experimented using lithium as a treatment for gout. They found uric acid to be a significant issue and several diseases. Lithium became a natural treatment for rheumatic and regular gal which is high levels of uric acid. In 1908, the Sears, Roebuck & Company advertised lithium tablets for people with uric acid issues.

In 1929, what we know today as 7-Up, the lemon-lime flavored soda, contained trace amounts of lithium which helps for mood stabilization and also diminished hangovers. Today it doesn't have lithium in it; they stopped this after 1950. The seven was for the atomic weight of the element lithium.

In 1949 Dr. John Cade experimented with high doses of lithium citrate and carbonate. He used it for treatment in manic-depressive illnesses and observed animals, then human trials. Lithium restored memory, improved mood, and cognitive function. It was discovered soon after there were severe side effects with individuals who had hypertension, and heart disease.

This is when the FDA stepped in and didn't want to support or promote the use of lithium anymore. Not until the 1970s was lithium orotate emerged as a supplement that could be beneficial with less risk. Today it is used in alternative medicine and sometimes supplemental to regular western medicine psychiatric treatments.

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Conclusion

The mineral can be used for a variety of medical and mental conditions. Someone can use it in addition to other treatments for a mental disease such as bipolar disorder. It is can be safe and effective at low doses and can regrow brain cells and prevent damage to brain cells if taken regularly. It is inexpensive as an over-the-counter supplement, reliable, powerful and safe.

Toxic levels are not an extreme concern at the low over-the-counter dosage in capsule form. This nutritional supplement can ease many symptoms of mental illness. If you have a mental illness, be evaluated by a psychiatric medical provider before taking this mineral.

Featured Image via Amazon

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